In 13 published case reports, symptoms occurred between 2 weeks and 6 months after omeprazole was commenced. 2 In 2 possible cases reported to CARM, the duration of therapy was around 18 months. Doses have been within the recommended range of 20mg or 40mg daily. In 4 of the published cases, the patients responded to withdrawal of omeprazole alone, but 6 other patients also received corticosteroid therapy. Some, including one of the cases reported to CARM, responded to corticosteroid therapy but did not fully recover until omeprazole was withdrawn. Initial recovery after omeprazole was withdrawn was usually rapid over a few days although full recovery of renal function took up to 2 to 3 months, and even longer in rare cases. There are no known reports of death as a result of this adverse reaction. In 4 of the published cases, renal function deteriorated again when omeprazole was reintroduced.
Drug induced autoimmune liver disease is a poorly defined and under-reported the liver disorder, and, probably, an underestimated liver disease [ 10 ]. Although DIAIH may develop after a prolonged use of a drug, it seems that DIAIH can be presented with acute hepatitis of unknown etiology. Female sex seems to be a risk factor for DIAH. Treatment decisions should be given according to patient’s clinical status and follow ups at acute presentations of DIAIH. There can be no treatment need, but, when needed generally a short course of immunosuppressive treatment can be sufficient without relapse opposed to idiopathic AIH.
My Son has Fetal Valproate Syndrome a type of Fetal Anti Convulsant Syndrome (FACS) caused by Sodium valproate (Epilim, Depakote, Depakene) that I took while pregnant to control epilepsy. Despite the 40% risk of birth defects the UK medicine regulator (MHRA) is refusing to issue warnings. A group of people affected by the harmful side effects of pharmaceutical products held a peaceful protest on 2nd August 2013 at the MHRA Headquarters in London. http:// is linking people affected by all medications to build up a global campaign to raise awareness of poor medicine regulation. I have put a link to this page on the front page of the website. If you would like to get involved in our global campaign please email me and join the public facebook group (Fetal AntiConvulsant Trust) to discuss strategy and the development of the campaign. I look forward to hearing from you. thank you. emma friedmann