Research Using the MOATT
A Structured Nursing Intervention at Dana-Farber Cancer Institute
Jean Boucher and colleagues published the results of a study designed to evaluate a nurse-led intervention using the MOATT with the goals of increasing patient knowledge and adherence to therapy. This was a longitudinal, descriptive, feasibility study conducted in an ambulatory thoracic oncology disease center at the Dana-Farber Cancer Institute in Boston, Massachusetts. Thirty adult patients with lung cancer, who were being treated with the oral agent erlotinib, participated in the study (with 27 completing).
Mefloquine is a chiral molecule with two asymmetric carbon centres, which means it has four different stereoisomers . The drug is currently manufactured and sold as a racemate of the ( R , S )- and ( S , R )-enantiomers by Hoffman-LaRoche , a Swiss pharmaceutical company. Essentially, it is two drugs in one. Plasma concentrations of the (–)-enantiomer are significantly higher than those for the (+)-enantiomer, and the pharmacokinetics between the two enantiomers are significantly different. The (+)-enantiomer has a shorter half-life than the (–)-enantiomer.