Ingestion of 400mg L-Ornithine a half hour before drinking alcohol (/kg 90 minutes before bed) was able improve some measurements taken the next morning (self-reported ratings of anger-hostility, confusion, sleep length, and fatgiue) and a reduction in cortisol in persons defined as 'flushers' (persons, usually asian, with a defect in the aldehyde dehydrogenase gene which metabolizes alcohol; 'flushers' are more sensitive to the effects of alcohol  ) but overall ethanol metabolism and the state of drunkedness were unaffected. 
Rich van Konynenburg has been in contact with patient and support groups and about 60 so far have gone through this regime. He seems to see two categories of effect - firstly sometimes a quite rapid and profound improvement in some of the common symptoms, or secondly symptoms worsening or new symptoms arise because in getting the methylation cycle going one suddenly starts to get detox and die off symptoms. The reason for this is that when the methylation cycle was not working the body was unable to detox properly and unable to produce cell mediated immune responses to get rid of chronic infections. Once the methylation cycle is up and running, suddenly the body can swing into action with respect to detox and cell mediated immune responses and this can make the person much worse. The reasons for this are fairly obvious - as soon as one starts to detox one mobilises chemicals and toxins into the blood stream, this makes people ill. Secondly, remember that it is not viruses and chronic infections that make one ill, it is the immune reaction against them. Cell medicated immune responses make you feel sick! So it is really important to go into this regime gently, be mindful that it may make things worse initially but see this as a good sign.