In their 2000 paper by Schinasi et al. published by the International Monetary Fund in 2001, the authors observed that the increase in OTC derivatives transactions would have been impossible "without the dramatic advances in information and computer technologies" that occurred from 1980 to 2000.  During that time, major internationally active financial institutions significantly increased the share of their earnings from derivatives activities. These institutions manage portfolios of derivatives involving tens of thousands of positions and aggregate global turnover over $1 trillion. At that time prior to the financial crisis of 2008, the OTC market was an informal network of bilateral counterparty relationships and dynamic, time-varying credit exposures whose size and distribution tied to important asset markets. International financial institutions increasingly nurtured the ability to profit from OTC derivatives activities and financial markets participants benefitted from them. In 2000 the authors acknowledged that the growth in OTC transactions "in many ways made possible, the modernization of commercial and investment banking and the globalization of finance."  However, in September, an IMF team led by Mathieson and Schinasi cautioned that "episodes of turbulence" in the late 1990s "revealed the risks posed to market stability originated in features of OTC derivatives instruments and markets. 
Muscle relaxer are drugs that eases pain, swelling, stiffness or any type of discomfort due to sprains, muscle injuries, strains and muscle spasms. But they do not really heal the defects but it can help in relieving the pain and relaxing the muscles. Over the counter muscle relaxants are quite convenient than prescribed drugs since you can easily get it anytime you want. The difference with prescribed drugs is that they are more potent thus they need to be carefully monitored by a doctor unlike muscle relaxants over the counter which you can easily buy without your doctors prescription. So that if over the counter relaxers do not work then it is time to go to your doctor for more powerful medications.
I have been joyously addicted 3 times in my life. I am 57 and now residing in Thailand. (NO drugs available here ON THE PAIN OF DEATH or life-long imprisonment. I like it.) My first addiction was to the lovely pink pills of “Optalidon”. It is an Italian formulation used as a pain killer. It is available only in Italy and is now doctor controlled. I was 16 years old when I discovered that 25 pills were available from any pharmacist for the equivalent of 75 american cents. I spent a year taking 5, and only 5, pills per day. Being high all day made school fun and raised my grades from B+ to A+. I smoked great hash, drank wonderful wine and tripped on REAL acid from Freshman to Senior year–but the euphoric high offered by these pink pills was unique, long lasting and made me smile like a fool. A year in a group of friends staged an intervention, (I had become far more wacky than they were used to.) So I quit. Spent the day in bed and threw up once and then all was grand.
Flash forward to a severe car crash in the US when I was aprox. 40 to 45 years old. Hospital for two weeks then home with script for 2 Vicodin every 4 hours. Of course that became 1 vicodin in the morning, 1 in the afternoon and the rest maintaining a great high in the evening. I loved them and they were easy to control. When, with no warning, they were cut-off. I missed them but experienced very, very mild withdrawal. A few years later I was depressed and called a friend who knew somebody who could get vicodin in bulk. So I started up again. Maybe it lasted 6 months. Again the easiest possible “withdrawal”.
I have recently started reading about “all those overdoses”. I have a few questions about the coverage:
1. How involved is the DEA in spreading these stories? (A couple Presidents have come right out and said “We have lost the war on drugs”.) If I worked at the DEA I would not want my job eliminated, nor would I want to be transferred by Homeland to where we really need coverage–like the immense dock facilities that are wide open to terrorists!
2. Why is Fentanyl being stuck into the heroin supply? Even the most ignorant drug dealer knows a dead junkie does not buy product!!
3. Why, since Alcohol kills and maims many more people directly and indirectly per year does no story produce graphs or pie charts, or just plain numbers, to let people know that drugs are not the demon we make them out to be.
I do not recommend taking heroin or a version of cocaine. They are both highly addictive and will control you. But everything else: research, beware the seller and enjoy!!!