Through its action on the pituitary, danazol indirectly reduces estrogen production by lowering the output of follicle-stimulating hormone and luteinizing hormone. There is also evidence that danazol binds to sex hormone receptors in target tissues, thereby exibiting anabolic, antiestrognic and weakly androgenic activity. With higher doses, amenorrhea generally occurs after about 6 weeks of therapy; ovulation and cyclic bleeding returns to normal 60—90 days after therapy is discontinued. Danazol is used to treat endometriosis because it causes atrophy of ectopic endometrial tissue, which relieves symptoms completely. It also decreases the growth rate of abnormal breast tissue, making it useful in fibrocystic breast disease. Heriditary angioedema is an inherited disorder characterized by a deficiency in C1 esterase inhibitor (C1 INH), a serum inhibitor of the activated first component of complement. Danazol increases circulating levels of C1 INH and therby increases C4 of the complement system, which also is deficient in hereditary angioedema. Consequently, danazol prevents attacks of hereditary angioedema in both males and females. The exact mechanism by which danazol increases C1 INH is not known. Danazol does not possess any progestogenic activity, and does not suppress normal pituitary release of corticotropin, or release of cortisol by the adrenal glands.
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It generally only takes a low dose of T3 to treat hypothyroidism. This will not necessarily promote enhanced fat loss, but it should return the metabolism back to proper working order. However, many performance enhancing athletes enjoy using triiodothyronine to in fact enhance direct fat loss. The use of Triiodothyronine alongside a calorie restricted diet will promote significant and accelerated fat loss. While effective, generally this type of use cannot be recommended without the use of anabolic steroids. Due to the necessarily higher doses needed to promote enhanced fat loss and due to the depletion of ATP (Adenosine triphosphate), this can promote lean tissue loss. The body will take whatever it needs from wherever it can get it to meet its energy demands. For this reason, an anabolic protectant is normally advised when supplementing with T3 for this purpose.