Potency of different topical steroids

To perform these tests, a g sample of flower is mixed with a test fluid. Very small samples of the mixture are precisely measured and applied with a pipette or capillary tube to a specially coated glass plate. The plate is then placed in a jar, standing in additional test fluid. The fluid then wicks up the plate, carrying the cannabinoids with it. The individual properties of the cannabinoids cause them to be left in line, in a particular color and specific order, up the plate. Once the plate is dry, it is sprayed with a dye to reveal the colored spots. The size of the spots is compared to a template, which determines potency results in increments of one percentage point.

The most "couchlock" or sedating effect happens towards the end of the pot harvest window, when the trichomes have become a darker color (usually amber/gold). The best results from amber trichomes come from indica strains. The amber/yellow trichomes contribute to a 'body high'. Some of the THC has converted into less psychoactive CBN, which has calming and anti-anxiety effects. With some strains, the trichomes will even turn red or purple! I like to harvest around when 20% have turned amber. At this point 70-90% of the pistils have darkened. Harvesting later will increase the sedating effects, but may also start reducing the psychoactive effects.

After a RRP, when and what are the possibilities for return of erections? Is an agent like Viagra or Cialis required to start or help in the recovery?
The chances of recovering erections depends upon the patient's age, how good his erections are before surgery, whether he takes medications for blood pressure or diabetes, how advanced the tumor is, the skill and experience of his surgeon, and whether or not he needs postoperative radiotherapy or hormonal therapy. Agents like Viagra are often helpful in speeding the return of erections.

AB - The Ranvier nodes of thick myelinated nerve fibers contain almost exclusively voltage-gated sodium channels (Navs), while the unmyelinated fibers have several receptors (., cannabinoid, transient receptor potential vanilloid receptor 1), too. Therefore, a nerve which contains only motor fibers can be an appropriate in vivo model for selective influence of Navs. The goals were to evaluate the potency of local anesthetic drugs on such a nerve in vivo; furthermore, to investigate the effects of ligands with different structures (arachidonic acid, anandamide, capsaicin and nisoxetine) that were proved to inhibit Navs in vitro with antinociceptive properties. The marginal mandibular branch of the facial nerve was explored in anesthetized Wistar rats; after its stimulation, the electrical activity of the vibrissae muscles was registered following the perineural injection of different drugs. Lidocaine, bupivacaine and ropivacaine evoked dose-dependent decrease in electromyographic activity, ., lidocaine had lower potency than bupivacaine or ropivacaine. QX-314 did not cause any effect by itself, but its co-application with lidocaine produced a prolonged inhibition. Nisoxetine had a very low potency. While anandamide and capsaicin in high doses caused about 50% decrease in the amplitude of action potential, arachidonic acid did not influence the responses. We proved that the classical local anesthetics have high potency on motor nerves, suggesting that this method might be a reliable model for selective targeting of Navs in vivo circumstances. It is proposed that the effects of these endogenous lipids and capsaicin on sensory fibers are not primarily mediated by Navs.

Potency of different topical steroids

potency of different topical steroids

AB - The Ranvier nodes of thick myelinated nerve fibers contain almost exclusively voltage-gated sodium channels (Navs), while the unmyelinated fibers have several receptors (., cannabinoid, transient receptor potential vanilloid receptor 1), too. Therefore, a nerve which contains only motor fibers can be an appropriate in vivo model for selective influence of Navs. The goals were to evaluate the potency of local anesthetic drugs on such a nerve in vivo; furthermore, to investigate the effects of ligands with different structures (arachidonic acid, anandamide, capsaicin and nisoxetine) that were proved to inhibit Navs in vitro with antinociceptive properties. The marginal mandibular branch of the facial nerve was explored in anesthetized Wistar rats; after its stimulation, the electrical activity of the vibrissae muscles was registered following the perineural injection of different drugs. Lidocaine, bupivacaine and ropivacaine evoked dose-dependent decrease in electromyographic activity, ., lidocaine had lower potency than bupivacaine or ropivacaine. QX-314 did not cause any effect by itself, but its co-application with lidocaine produced a prolonged inhibition. Nisoxetine had a very low potency. While anandamide and capsaicin in high doses caused about 50% decrease in the amplitude of action potential, arachidonic acid did not influence the responses. We proved that the classical local anesthetics have high potency on motor nerves, suggesting that this method might be a reliable model for selective targeting of Navs in vivo circumstances. It is proposed that the effects of these endogenous lipids and capsaicin on sensory fibers are not primarily mediated by Navs.

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