Another side effect that is occasionally seen in dogs taking steroids for various health concerns is changes in behavior. It's not uncommon to see your pet become suddenly more aggressive or anxious after giving him steroids. Dogs that were otherwise very mild mannered and well behaved may begin to run around or bark. In more extreme cases, you may need to be careful about the possibility of your dog biting or harming someone. Mood changes can also make your pet more sedate and depressed as well, so it's important to also be on the lookout for other types of adjustments in behavior.
Cortisone injections are extremely safe, but they do still have potential problems. If you are concerned about having a cortisone shot, talk with your doctor. While cortisone is a powerful treatment for many orthopedic conditions, there are usually other options that can also be tried. Many doctors will offer an injection as they are quick, easy, and most often effective. However, your doctor should also be able to offer other treatments for inflammation that may also be effective for those that cannot have, or don't want, a cortisone injection.
Corticosteroid myopathy presents as weakness and wasting of the proximal limb and girdle muscles and is generally reversible following cessation of therapy.
Corticosteroids inhibit intestinal calcium absorption and increase urinary calcium excretion leading to bone resorption and bone loss. Bone loss of 3% over one year has been demonstrated with prednisolone 10 mg per day. Postmenopausal females are particularly at risk for loss of bone density. Sixteen percent of elderly patients treated with corticosteroids for 5 years may experience vertebral compression fractures. One author reported measurable bone loss over two years in women on concomitant therapy with prednisolone mg per day and tamoxifen. [ Ref ]