Dr. Randolph, we could really use your advice. I took my 16 year old cat, Sweetie, into the vet for a regular checkup as she had inappropriately urinated outside of her litter box (3) times over (3) months. In the past she had done this when she had some abscessed teeth, so I wanted to see what she was trying to tell us. The vet suggested routine blood work and urine analysis and this showed us that she had elevated BUN and Creatine levels, along with elevated white blood cells – they explained that meant she had early renal/kidney failure then went on to tell me that they also found signs of an upper urinary tract infection and recommended an antibiotic to cure it. They said i could come in the very next day to get the shot and it would last for 2 weeks to clear the infection and we should be able to manage the kidneys with a diet. I was not made aware of any possible side effects or risks with this shot, they really urged that it was the best option. After getting all of this news, I wanted to do anything I can to help her, the last thing I want is for her to be in pain.
Cells of the zona fasciculata and zona reticularis lack aldosterone synthase (CYP11B2) that converts corticosterone to aldosterone, and thus these tissues produce only the weak mineralocorticoid corticosterone. However, both these zones do contain the CYP17A1 missing in zona glomerulosa and thus produce the major glucocorticoid, cortisol. Zona fasciculata and zona reticularis cells also contain CYP17A1, whose 17,20-lyase activity is responsible for producing the androgens, dehydroepiandrosterone (DHEA) and androstenedione. Thus, fasciculata and reticularis cells can make corticosteroids and the adrenal androgens, but not aldosterone.