I have been receiving IVIG for nearly 9 yrs. At first, I used Gammunex with fairly mild side effects. Then my supplier insisted it was no longer available and put me on Gammagard that caused bad headaches, fatigue, pain and some nausea. I finally wrote to IG Living regarding how I could get back to Gammunex. They quickly responded that all I needed to do was have my doctor write an RX for "Gammunex Only" and that did it!! I do much better now. My premeds are 400 mg Ibuprofen, 25 Benadryl, 50 mg IV solu-cortef pre and post treatment. I also take my RX headache meds and pain meds as I also suffer from FM and chronic fatigue. I am doing much better now and no longer have to wipe out my schedule for a week after tx! Thank God for the resource of IG Living! I do have problems sleeping the first and often second night after tx that I am sure is due to the steroid. I just block out a few days to adjust and rest when I can. But, so much better than I did with Gammagard!!
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Sacks et al. (2005) reported the case of a 72-year-old man, described as professionally successful, intelligent, and cultivated, with polymyalgia rheumatica, who after being treated with prednisone developed a psychosis and dementia , which several behavioral neurology and neuropsychiatry consultants initially diagnosed as early dementia or Alzheimer's disease .  Large dosage variations in the patient's medication (including a self-increased dosage from 10 mg/day to as much as 100 mg/day for at least 3 months) produced extreme behavioral changes, from missed appointments to physical altercations, and eventually admission to a psychiatric ward and later to a locked Alzheimer facility. During this time, neuropsychological testing showed a decline in the patient's previously superior IQ as well as deficits in memory, language, fluency, and visuospatial function, which given the patient's age was considered to be compatible with early dementia. When the steroid treatment ended after a year, the patent's confusion and disorganized appearance stopped immediately. Within several weeks, testing showed strong improvement in almost all cognitive functions. His doctors were surprised at the improvement, since the results were inconsistent with a diagnosis of dementia or Alzheimer's. Testing after 14 months showed a large jump in Full Scale IQ from 87 to 124, but mild dysfunction in executive function, memory, attentional control, and verbal/nonverbal memory remained.